National Lung Screening Trial (NLST)

The National Lung Screening Trial (NLST) was a randomized controlled trial conducted by the Lung Screening Study group (LSS) and the American College of Radiology Imaging Network (ACRIN) to determine whether screening for lung cancer with low-dose helical computed tomography (CT) reduces mortality from lung cancer in high-risk individuals relative to screening with chest radiography. Approximately 54,000 participants were enrolled between August 2002 and April 2004. Data collection has ended, and information is complete through December 31, 2009. NLST has the ClinicalTrials.gov registration number NCT00047385.